Bacillus subtilis is a rod shaped, Gram-positive bacterium. It is found in soil and the gastrointestinal tract of ruminants and humans. Bacillus subtilis is considered as an ideal probiotic as it is found as a normal gut commensal in humans and it has ability to tolerate extreme environmental conditions. It is considered a tough probiotic because it can form a protective endospore to keep itself alive almost indefinitely. It tolerates extreme environmental conditions of temperature and desiccation. It is stable at extreme pH levels and high temperatures, can survive desiccation as well as challenging storage/ manufacturing conditions, and the gastric environment in the stomach. Bacillus subtilis SNZ 1972 is a GRAS approved ingredient.
History of Use
It was originally named Vibrio subtilis by Christian Gottfried Ehrenberg , and renamed Bacillus subtilis by Ferdinand Cohn in 1872 (subtilis being the Latin for ‘fine’). B. subtilis has historically been classified as an obligate aerobe , though evidence exists that it is a facultative anaerobe . This bacterium is also known by the names hay bacillus, grass bacillus, or Bacillus globigii.
Proven Stability in a
variety of dosage forms
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