Bacillus subtilis is a rod shaped, Gram-positive bacterium. It is found in soil and the gastrointestinal tract of ruminants and humans. Bacillus subtilis is considered as an ideal probiotic as it is found as a normal gut commensal in humans and it has ability to tolerate extreme environmental conditions. It is considered a tough probiotic because it can form a protective endospore to keep itself alive almost indefinitely. It tolerates extreme environmental conditions of temperature and desiccation. It is stable at extreme pH levels and high temperatures, can survive desiccation as well as challenging storage/ manufacturing conditions, and the gastric environment in the stomach. Bacillus subtilis SNZ 1972 is a GRAS approved ingredient.
History of Use
It was originally named Vibrio subtilis by Christian Gottfried Ehrenberg , and renamed Bacillus subtilis by Ferdinand Cohn in 1872 (subtilis being the Latin for ‘fine’). B. subtilis has historically been classified as an obligate aerobe , though evidence exists that it is a facultative anaerobe . This bacterium is also known by the names hay bacillus, grass bacillus, or Bacillus globigii.
Bacillus subtilis is a known probiotic for enhancing immune system. The potential of B. subtilis to produce antibiotics has been recognized for 50 years. B. subtilis enhances the protection against pathogens by stimulating nonspecific and specific immunity.
Bacillus subtilis is known for its ability to produce B- vitamins and is highly enzymatic in nature. It helps in maintenance of intestinal homeostasis by maintaining epithelial integrity and barrier function. It can be utilized to treat antibioticsinduced colitis, inflammatory bowel disease (IBD) (including Crohn’s disease and ulcerative colitis) and necrotizing enterocolitis.
B. subtilis quorum sensing molecule, pentapeptide CSF (competence and sporulation factor) helps in reducing epithelial injury caused by intestinal inflammation and showed improvement in survival rate of mice with lethal colitis. This indicates that B. subtilis are potentially useful for treating intestinal inflammation.
Proven Stability in a
variety of dosage forms