Bacillus Coagulans

Our FDA GRAS and Infant GRAS approved flagship strain: Bacillus coagulans SNZ 1969® is unique in the space of spore forming probiotic strains. It boasts an exceptional history of use, stability profile, research and genetic pedigree. Combined with Sanzyme’s experience in end-to-end production and decades of continuous technological improvement, SNZ 1969™ is a reliable, long-term choice for inclusion in supplements, foods, and pharmaceutical formulations.

  • 50 years of safe use across age group
  • Most studied and used Bacillus coagulans probiotic strain
  • 150 million doses in more than 40 countries

Benefits of using probiotic strain Bacillus coagulans SNZ 1969®

Science Backed

Bacillus coagulans SNZ 1969® is backed by more than 30 human studies confirming health benefits including digestive health, oral health and women’s health.

Clinical Reference

  • Evaluation of efficacy and safety of Bacillus coagulans SNZ 1969 supplementation for irritable bowel syndrome: a randomized, double-blind, placebo-controlled study.

    Soman R.J., Gorantla S.C., Swamy M.V., International Journal of Basic & Clinical Pharmacology, 2022. Nov;11(6)

  • Efficacy and Safety of Probiotic Bacillus coagulans- SNZ 1969 in Gastrointestinal Discomfort: A Randomized, Placebo-Controlled Study.

    Soman R.J., Singh K., Swamy M.V. International Journal of Health Sciences and Research, 2022. Vol.12; Issue: 3

  • Spore-forming Bacillus coagulans SNZ 1969 improved intestinal motility and constipation perception mediated by microbial alterations in healthy adults with mild intermittent constipation: A randomized controlled trial.

    Kang S., Park M.Y., Brooks I., Lee J., Kim S. H., Kim J. Y., Oh B., Kim J.W., Kwon O. Food Research International 2021. 146, 110428

  • The Efficacy and Safety of Combined Senna & Probiotic-Based Bowel Preparation for Colonoscopy in Children.

    Kesavelu D. Cureus, 2020. 12 (9): e10180.

  • Clinical trial of Sporlac in gastroenteritis.

    Ronald Ross Institute of Tropical Diseases, Hyderabad. 1999 (Unpublished)

  • Comparative evaluation of locally delivered probiotic paste and chlorhexidine gel as an adjunct to scaling and root planning in treating chronic periodontitis: A split-mouth randomized clinical trial.

    Vishnusripriya J., Melath A., Feroz M., Subair K., and Chandran N J Indian Soc Periodontol. 2022. May-Jun; 26(3): 262–268.

Over 5 Decades History of Use Across Age Groups

Bacillus coagulans SNZ 1969® has been used for the last five decades across age groups in various applications delivering health benefits.


Different Probiotics strains have varied sensitivity levels. All probiotic strains are not process stable or survive stringent conditions.

SNZ 1969® enjoys the following advantages –

  • High thermal stability
  • No refrigeration required
  • Tolerates low pH and osmotic pressure
  • Survives gastric acid barrier and bile

Unlimited Innovation Opportunity



  • The technology for the production of SNZ 1969 and the mother culture was transferred via technology transfer by Sankyo Japan in 1972
  • Strain was isolated from green malt and is a sister strain to the original Nakamura strain

Proven Stability in a
multiple application formats















Disclaimer: These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.