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Probiotics for Poultry

Probiotics for Poultry: Stress and Diarrhoea management

Author Sanzyme Biologics Posted on

In the dynamic world of poultry farming, maintaining optimal health is paramount to ensure productivity and profitability. However, challenges such as stress and gastrointestinal issues like diarrhoea can disrupt poultry well-being, impacting both bird performance and farm economics. Fortunately, the integration of probiotics offers a promising solution for addressing these concerns effectively. In this comprehensive guide, we delve into the role of Probiotics in alleviating stress and managing diarrhoea in poultry, exploring their mechanisms of action and highlighting their significance for sustainable poultry production.

Understanding Probiotics: Probiotics, often hailed as “good bacteria,” are live microorganisms that confer health benefits when consumed in adequate amounts. In poultry farming, Probiotics primarily comprise beneficial bacterial strains like Lactobacillus, Bifidobacterium and Bacillus species. These Probiotic bacteria play a pivotal role in promoting gut health, modulating immune function, and supporting overall well-being in poultry.

Stress and Its Impact on Poultry Health:

Stress is an unavoidable aspect of intensive poultry production arising from factors such as housing, environmental fluctuations, production & reproduction, infections, transportation and management practices. When poultry experience stress, it results in immunological or metabolic consequences such as:

  • Regression of immune protective organs
  • Reduction of the oxidative metabolic capacity of mitochondria
  • Deficit of antioxidant reserves
  • Changes in the activity of antioxidant enzymes
  • Disruption of the gut mocrobiota

All these have a high adverse effect on the poultry bird leading to immune suppression, high susceptibility to infectious pathogens, loose droppings / diarrhoea, high FCR, decreased body weight, decreases egg production, soiled eggs, infertility / low egg hatchability and finally low ROI.

Physiological stress in particular to laying hens & breeder females is a major cause of concern, when they are turning from pre-lay to peak-lay. Physiological stress during this stage is due to rapidly   developing ovaries & fallopian tubes along with an Estrogen surge. This increases nutritional requirement causing a burden on the digestive system. Because the Gut-Brain Axis takes a beating, immunity is hampered, pathogenic invasion & proliferation is rampant causing imbalance of intestinal flora which manifests to diarrhoea / loose droppings, vent pasting and soiled eggs.

Role of Probiotics in Stress Alleviation for poultry:

Probiotics offer a multifaceted approach to mitigating the negative effects of stress on poultry health. Through various mechanisms, Probiotics help modulate the stress response and enhance resilience in birds. Probiotic strains have been shown to downregulate the production of stress hormones and promoting a calmer physiological state in poultry. Additionally, Probiotics bolster gut health by strengthening the intestinal barrier and regulating immune function, thereby supporting birds in coping with stressors more effectively.

Managing Diarrhoea in Poultry:

Diarrhoea is a prevalent gastrointestinal ailment in poultry, characterized by loose or watery faeces and associated symptoms like dehydration and reduced feed intake. The causes of diarrhoea in poultry are diverse, ranging from infectious agents to dietary factors and stress. Regardless of the underlying cause, diarrhoea poses significant challenges to poultry health and farm profitability.

The Role of Probiotics in Diarrhoea Management:

Probiotics play a crucial role in managing diarrhoea in poultry by promoting gastrointestinal health and combating pathogenic bacteria. Unlike conventional antibiotics, which indiscriminately kill both harmful and beneficial bacteria, further impairing gut microbiota thereby hampering immunity and production. Probiotics target pathogens while preserving & nurturing the beneficial microflora in the gut. Probiotic bacteria outcompete pathogenic organisms for resources and adhesion sites in the intestinal mucosa, thereby reducing their colonization and proliferation. Moreover, Probiotic strains produce antimicrobial compounds like bacteriocins which inhibit the growth of pathogens contributing to diarrhoea resolution and prevention.

Choosing the Right Probiotic Strains

Selecting the appropriate Probiotic strains is paramount for achieving desired outcomes in poultry production. When choosing Probiotics for stress alleviation and diarrhoea management, factors such as strain specificity, viability, and compatibility with existing management practices must be considered. It’s essential to opt for Probiotic strains that have been scientifically validated for their efficacy in poultry health. Consulting with poultry health experts, nutritionists and veterinarians can aid in selecting the most suitable Probiotic strains for addressing specific health challenges in poultry flocks.

Applications of Probiotics in Poultry Farming:

Probiotics can be conveniently administered to poultry through various routes including feed and water. Incorporating probiotics into feed formulations is a common and effective method of delivery, ensuring consistent dosing and maximum efficacy. Probiotic supplements can also be added to drinking water. Regardless of the administration route, adherence to recommended dosage guidelines and proper storage practices is essential to maintain Probiotic viability and efficacy.

Sporich ResQ is a Probiotic formulation developed by SANZYME BIOLOGICS aimed at addressing poultry diarrhoea due to pathogens, stress, physiological or of unknown etiology. Sporich ResQ contains beneficial microorganisms – Bacillus coagulans (SAN 135BC) and Saccharomyces boulardii (SAN 158SB), which play a vital role in maintaining the balance of gut microbiota in poultry. Both Bacillus coagulans (SAN 135BC) and Saccharomyces boulardii (SAN 158SB) have been documented to specifically act in:

  1. Stimulating the immune system
  2. Synthesising different antimicrobial bacteriocins to inhibit pathogens
  3. Producing enzyme metabolites to improve nutrient digestion and absorption
  4. Modulating and colonizing the gut with beneficial microbes

Thus promoting a healthy gut environment, reducing stress and improving production parameters.

Sporich ResQ acts by:

  1. Restoration of Gut Microflora Balance: Diarrhoea often occurs due to disruptions in the gut microbiota, such as the overgrowth of pathogenic bacteria. Sporich ResQ helps restore the balance of gut microflora by promoting the growth of beneficial bacteria, such as Lactobacillus and Bifidobacterium, which can outcompete harmful bacteria by reducing microbial count of Clostridium perfringens in both jejunum and ileum, thus controlling associated diarrhoea.
  2. Reduction of Antibiotic Usage: In many cases, antibiotics have been traditionally used to manage diarrhoea in poultry. However, overuse of antibiotics can lead to the development of Antibiotic-Resistant Bacteria which pose risks to human health. Sporich ResQ offers a natural alternative to antibiotics, reducing the reliance on antimicrobial agents in poultry farming.
  3. Enhanced Nutrient Absorption: Diarrhoea can lead to malabsorption of nutrients in poultry, resulting in poor growth and performance. Sporich ResQ restores Villi Height & Crypt Depth, thus facilitating better nutrient absorption, allowing poultry birds to utilize feed more efficiently and support optimal growth.
  4. Improved Flock Health and Performance: Ultimately, the use of Sporich ResQ leads to improved overall flock health and performance. By reducing the incidence and severity of diarrhoea, poultry farmers can expect healthier birds, good & clean eggs, better growth rates, FCR’s and overall profitability.
  5. Reducing the Risk of AMR: Both Bacillus coagulans (SAN 135BC) and Saccharomyces boulardii (SAN 158SB) – the Probiotic strains in Sporich ResQ have been tested for AMR Genes and have been documented as AMR Gene Negative. This goes a long way in Sporich ResQ being a potential candidate for reducing the risk of AMR which is posing a serious threat to humanity.

About SANZYME BIOLOGICS: A pioneer in fermentation technology with over 50 years of legacy in the area of Probiotics, SANZYME BIOLOGICS was founded as Uni-Sankyo in the year 1969 – a joint venture with Diachi Sankyo of Japan. SANZYME BIOLOGICS was the first company to manufacture and sell Probiotics & Enzymes in India and is today a market leader with presence in over 40 countries across the globe.

SANZYME BIOLOGICS manufactures proprietary Probiotic strains, Probiotic blends, enzymes and nutritional ingredients for humans, pets and farm animals in its state-of-the-art manufacturing facility in Hyderabad, India with fermentation capacity of over 350,000 L (one of the highest in the world).

SANZYME BIOLOGICS is certified FAMI-QS, NON-GMO, NSF, HALAL, KOSHER & ISO, producing a wide range of spore forming, shelf and process stable Probiotic strains. In Animal Health SANZYME BIOLOGICS exports AMR Gene Free Probiotic strains of Bacillus subtilis (SAN 144BS), Bacillus coagulans (SAN 135BC), Bacillus licheniformis (SAN 136BL) & Saccharomyces boulardii (SAN 158SB) and also specific formulations containing these Probiotic strains

Probiotics in shrimp farming

Probiotics in Shrimp Farming

Author Sanzyme Biologics Posted on

Introduction

Shrimp Farming has witnessed tremendous growth in recent years, becoming a vital sector in the global seafood industry. As the demand for high-quality shrimp continues to rise, farmers are faced with challenges such as disease outbreaks, water quality issues, and the need for sustainable practices. One promising solution gaining attention is the use of probiotics in shrimp farming.

Challenges in Shrimp farming

Shrimp farming presents numerous challenges due to constant exposure to pathogen pressures, environmental fluctuations (such as temperature, salinity, dissolved oxygen, etc.), and various production stressors (including stocking density and handling). However, the most formidable obstacle for producers is disease, which can result in unpredictable harvests with mortality rates ranging from 30% to 80%. This unpredictability significantly heightens the risk of shrimp farming and incurs substantial financial costs, estimated to cost the shrimp industry billions of US dollars annually. Despite extensive research, finding a singular solution to address these intricate challenges remains elusive and unrealistic. Therefore, a comprehensive, multifactorial approach is imperative throughout the value and production chain, necessitating collaboration among various stakeholders.

Understanding Probiotics

Probiotics, often referred to as “good bacteria,” are living microorganisms that confer health benefits to their host organisms when administered in adequate amounts. In shrimp aquaculture, the most commonly used probiotics include bacteria, yeast, and other microorganisms that positively influence the gut microbiota of shrimp.

The Gut Microbiota and Shrimp Health

The gastrointestinal tract of shrimp plays a crucial role in digestion, nutrient absorption, and overall health. Disruptions in the balance of the gut microbiota can lead to various issues, including disease susceptibility and poor growth rates. Probiotics work by enhancing the beneficial bacteria in the shrimp gut, thereby promoting a healthier microbial community.

Benefits of Probiotics in Shrimp Aquaculture

Disease Prevention: Probiotics have shown remarkable potential in preventing and controlling diseases in shrimp. They compete with harmful pathogens for resources, produce antimicrobial compounds, and stimulate the shrimp’s immune system.

Improved Nutrient Digestion: Certain probiotic strains assist in the breakdown of complex nutrients, making them more accessible to the shrimp. This results in improved feed utilization and better growth rates.

Water Quality Management: Probiotics contribute to the maintenance of water quality by breaking down organic matter and reducing the accumulation of harmful compounds such as ammonia and nitrites. This is particularly crucial in densely populated shrimp ponds.

Stress Reduction: Shrimp often face stressors such as changes in environmental conditions or handling during farming operations. Probiotics help in mitigating stress by promoting a balanced gut microbiota, which in turn supports the shrimp’s resilience.

Application of Probiotics in Shrimp Farming

Probiotics can be administered to shrimp through various methods:

Direct Addition to Feed: Probiotics can be incorporated into shrimp feed, ensuring a consistent and controlled dosage. This method is convenient for large-scale farming operations.

Water Probiotics: Some farmers prefer adding probiotics directly to the pond water. This allows for a more widespread distribution and can positively impact the entire pond ecosystem.

Post-Larval Treatment: Treating shrimp post-larvae with probiotics during the early stages of development establishes a beneficial microbial community in the gut, laying the foundation for a healthy life cycle.

Challenges and Considerations

While the use of probiotics in shrimp aquaculture holds tremendous potential, it is essential to address challenges such as:

Selection of Strains: Identifying the most effective probiotic strains for a specific shrimp species and environmental conditions is crucial.

Dosage and Timing: Determining the optimal dosage and timing of probiotic administration requires careful consideration to achieve maximum benefits.

Environmental Factors: Factors like water temperature, pH, and salinity can influence the effectiveness of probiotics, making it necessary to tailor applications to specific conditions.

Probiotic solution for shrimp farming from Sanzyme Biologics

Sanzyme Biologics has positioned itself at the forefront of innovation by offering a specialized probiotic solution for aquaculture designed to tackle the unique challenges faced by shrimp farmers. Their approach is holistic, targeting the host, pathogen, and environment to fortify shrimp health and resilience.

Host Support: Sanzyme’s probiotics are formulated to enhance the shrimp’s immune system and digestive processes. By fostering a balanced gut microbiota, these probiotics contribute to improved nutrient absorption and overall health for shrimps.

Pathogen Control: The probiotic solution from Sanzyme Biologics includes strains that compete with and inhibit the growth of harmful pathogens. This proactive approach helps prevent disease outbreaks and reduces mortality rates.

Environmental Management: Recognizing the impact of environmental factors, Sanzyme’s probiotics for aquaculture aid in maintaining optimal conditions within shrimp ponds. This includes mitigating the effects of fluctuating temperatures, salinity levels, and other stressors.

While the financial toll of high mortality rates in shrimp farming is difficult to quantify precisely, Sanzyme Biologics’ probiotic solution aims to significantly reduce these losses. By offering a more predictable and consistent harvest, shrimp farmers can experience increased profitability and sustainability, reinforcing the economic viability of the entire industry.

About Sanzyme Biologics

Sanzyme Biologics is a pioneer in fermentation technology with 50 years of legacy in the area of probiotics.  Founded as Uni-Sankyo in the year 1969, it was the first company to manufacture and sell probiotics & enzymes in India and is today a market leader with presence in over 40 countries across the globe, including key markets such as US, Europe, Japan, South Korea, Australia, New Zealand, China and Taiwan.

Sanzyme Biologics manufactures proprietary probiotic strains, probiotic blends, enzymes and nutritional ingredients for humans, pets and farm animals in its state-of-the-art manufacturing facility in Hyderabad, India with over fermentation capacity of 350,000 L (one of the highest in the world). Sanzyme Biologics is certified FAMI-QS, NON-GMO, NSF, HALAL, KOSHER & ISO   Producing a wide range of spore forming, shelf and process stable probiotic strains. In Animal Health -Sanzyme Biologics  exports AMR Gene Free Probiotic strains of Bacillus subtilis (SAN 144BS), Bacillus coagulans (SAN 135BC), Bacillus licheniformis (SAN 136BL) & Saccharomyces boulardii (SAN 158SB). SANZYME BIOLOGICS also export other Probiotic Animal Health Formulations for Poultry, Aqua, Swine, Dairy, Sheep, Companion Animals & Others

Bacillus clausii Oral Suspension: Effective probiotics shots

Author Sanzyme Biologics Posted on

Introduction

The human body is home to trillions of microorganisms that play a pivotal role in maintaining our health. Among these microorganisms, probiotics are gaining popularity due to their potential health benefits. Bacillus clausii, a probiotic strain, has been the subject of considerable research and has shown promising effects on various health conditions. One of the common forms of Bacillus clausii is the oral suspension, which has gained widespread recognition for its ease of use and potential therapeutic properties. In this blog, we will delve into the world of Bacillus clausii oral suspension, exploring its uses, benefits, dosage, side effects, and current research findings.

What is Bacillus clausii oral suspension?

Bacillus clausii is a spore-forming, Gram-positive bacterium that naturally resides in the soil. It has been identified as a probiotic with the ability to form spores, which can withstand adverse conditions such as heat, acidity, and other harsh environments. Due to this unique characteristic, Bacillus clausii can survive the acidic environment of the stomach and reach the intestine in an active form, where it exerts its beneficial effects

The Mechanism of Action

Bacillus clausii oral suspension operates by restoring and maintaining a balanced gut flora. The gastrointestinal tract is home to a complex community of microorganisms, collectively known as the gut microbiota, which plays a crucial role in digestive health, immune function, and overall well-being. Stress, poor dietary habits, antibiotic use, and various other factors can disrupt this delicate balance, leading to gastrointestinal disturbances.

When ingested, Bacillus clausii colonizes the gut and competes with harmful bacteria for nutrients and space, thereby promoting a healthier gut environment. It also produces antimicrobial substances, such as bacteriocins, which directly inhibit the growth of harmful bacteria. Furthermore, Bacillus clausii has been shown to stimulate the production of immunoglobulins, which enhance the immune response and help fight off infections.

Uses of Bacillus clausii Oral Suspension

Gastrointestinal Disorders: Bacillus clausii oral suspension is commonly used to alleviate symptoms associated with gastrointestinal disorders. These disorders include acute diarrhoea, chronic diarrhoea, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD). Clinical trials have demonstrated that Bacillus clausii can reduce the duration and severity of diarrhoea episodes, making it an effective adjuvant treatment.

 Antibiotic-Associated Diarrhoea (AAD): One of the most common side effects of antibiotic use is diarrhoea, which occurs due to the disruption of the gut microbiota. Bacillus clausii has been shown to reduce the risk of AAD by maintaining the balance of the gut microbiota during antibiotic therapy.

Prevention of Recurrent Respiratory Tract Infections (RTIs): Bacillus clausii has immune-modulating properties that may help reduce the recurrence of respiratory tract infections, such as common colds and flu.

Irritable Bowel Syndrome (IBS): Some studies suggest that Bacillus clausii may provide relief from IBS symptoms, such as bloating, gas, and abdominal discomfort, although further research is needed to establish its efficacy.

Allergies and Atopic Dermatitis: Early research indicates that Bacillus clausii might help in managing allergic conditions and atopic dermatitis due to its immunomodulatory effects.

Dosage and Administration of Bacillus clausii oral suspension

The dosage of Bacillus clausii oral suspension can vary depending on the patient’s age, condition, and severity of symptoms. It is crucial to follow the healthcare professional’s advice or the manufacturer’s instructions regarding dosage and administration.

In general, the oral suspension is available in single-dose vials or multi-dose bottles. It is usually taken orally, directly or mixed with water or other beverages. Shake the bottle well before use to ensure an even distribution of the spores.

For adults and children, the recommended dosage may range from 1 to 2 vials per day, divided into two to three doses. Children under two years of age may require a lower dosage. Always consult a healthcare professional, especially when administering Bacillus clausii to infants or young children.

Sanzyme Biologics expertise in manufacturing Bacillus clausii oral suspension

If you are seeking a reliable and experienced partner for private label manufacturing of Bacillus clausii oral suspension, with a proven track record in the pharmaceutical industry, Sanzyme Biologics is your go-to solution for high-quality probiotic products. As a leading contract manufacturer, we understand the critical importance of producing safe, effective, and compliant products that meet your brand’s unique requirements.

Expertise in Probiotic Formulations:   At Sanzyme Biologics, our team of skilled scientists and researchers are well-versed in probiotic formulations and the specific needs of Bacillus clausii oral suspension production. We utilize state-of-the-art technology and adhere to stringent quality control measures throughout the manufacturing process. From strain selection and culture development to formulation and packaging, every step is carefully optimized to ensure the highest quality end product.

Flexible and Customizable Solutions: We understand that each brand has its own identity and target market. With our private label manufacturing services, you have the flexibility to customize the Bacillus clausii oral suspension to align perfectly with your brand’s vision and objectives. Our team works closely with you to understand your requirements and offer tailored solutions, including variations in dosage, packaging, and product presentation.

Quality Assurance and Compliance: At Sanzyme Biologics, quality assurance is at the core of everything we do. We are committed to adhering to the highest industry standards and regulations. Our manufacturing facilities are equipped with cutting-edge technologies and comply with Good Manufacturing Practices (GMP). Additionally, our team of experts ensures that each batch of Bacillus clausii oral suspension undergoes rigorous testing for potency, purity, and safety, providing you and your customers with peace of mind.

Efficient Production and Timely Delivery: Time is of the essence in the fast-paced pharmaceutical industry, and we understand the importance of timely delivery. With streamlined production processes and an efficient supply chain, we strive to meet your manufacturing deadlines promptly without compromising on quality. Our dedication to meeting timelines ensures that your brand can launch and distribute Bacillus clausii oral suspension products to the market with confidence.

Regulatory Support: Navigating the regulatory landscape can be complex, but you don’t have to do it alone. Sanzyme Biologics provides comprehensive regulatory support to ensure that your Bacillus clausii oral suspension complies with all applicable regulations and requirements. Our team is well-versed in regulatory frameworks across various regions, enabling us to help you obtain the necessary certifications and approvals for seamless market entry.

Long-Term Partnership: Choosing Sanzyme Biologics as your private label manufacturing partner means forging a long-term collaboration. We prioritize building strong and lasting relationships with our clients, providing ongoing support even after product delivery. As your trusted partner, we are committed to helping your brand grow and succeed in the competitive probiotics market.

When it comes to private label manufacturing of Bacillus clausii oral suspension, Sanzyme Biologics stands as a dependable and experienced partner. Our expertise in probiotic formulations, commitment to quality and compliance, flexible and customizable solutions, and efficient production processes make us the ideal choice for your brand. With Sanzyme Biologics by your side, you can be confident in delivering top-notch Bacillus clausii oral suspension products that meet the highest industry standards and cater to your target market’s needs. Partner with us today to embark on a successful probiotics journey and achieve mutual success in the thriving healthcare industry.