Probiotics in Shrimp Farming


Shrimp Farming has witnessed tremendous growth in recent years, becoming a vital sector in the global seafood industry. As the demand for high-quality shrimp continues to rise, farmers are faced with challenges such as disease outbreaks, water quality issues, and the need for sustainable practices. One promising solution gaining attention is the use of probiotics in shrimp farming.

Challenges in Shrimp farming

Shrimp farming presents numerous challenges due to constant exposure to pathogen pressures, environmental fluctuations (such as temperature, salinity, dissolved oxygen, etc.), and various production stressors (including stocking density and handling). However, the most formidable obstacle for producers is disease, which can result in unpredictable harvests with mortality rates ranging from 30% to 80%. This unpredictability significantly heightens the risk of shrimp farming and incurs substantial financial costs, estimated to cost the shrimp industry billions of US dollars annually. Despite extensive research, finding a singular solution to address these intricate challenges remains elusive and unrealistic. Therefore, a comprehensive, multifactorial approach is imperative throughout the value and production chain, necessitating collaboration among various stakeholders.

Understanding Probiotics

Probiotics, often referred to as “good bacteria,” are living microorganisms that confer health benefits to their host organisms when administered in adequate amounts. In shrimp aquaculture, the most commonly used probiotics include bacteria, yeast, and other microorganisms that positively influence the gut microbiota of shrimp.

The Gut Microbiota and Shrimp Health

The gastrointestinal tract of shrimp plays a crucial role in digestion, nutrient absorption, and overall health. Disruptions in the balance of the gut microbiota can lead to various issues, including disease susceptibility and poor growth rates. Probiotics work by enhancing the beneficial bacteria in the shrimp gut, thereby promoting a healthier microbial community.

Benefits of Probiotics in Shrimp Aquaculture

Disease Prevention: Probiotics have shown remarkable potential in preventing and controlling diseases in shrimp. They compete with harmful pathogens for resources, produce antimicrobial compounds, and stimulate the shrimp’s immune system.

Improved Nutrient Digestion: Certain probiotic strains assist in the breakdown of complex nutrients, making them more accessible to the shrimp. This results in improved feed utilization and better growth rates.

Water Quality Management: Probiotics contribute to the maintenance of water quality by breaking down organic matter and reducing the accumulation of harmful compounds such as ammonia and nitrites. This is particularly crucial in densely populated shrimp ponds.

Stress Reduction: Shrimp often face stressors such as changes in environmental conditions or handling during farming operations. Probiotics help in mitigating stress by promoting a balanced gut microbiota, which in turn supports the shrimp’s resilience.

Application of Probiotics in Shrimp Farming

Probiotics can be administered to shrimp through various methods:

Direct Addition to Feed: Probiotics can be incorporated into shrimp feed, ensuring a consistent and controlled dosage. This method is convenient for large-scale farming operations.

Water Probiotics: Some farmers prefer adding probiotics directly to the pond water. This allows for a more widespread distribution and can positively impact the entire pond ecosystem.

Post-Larval Treatment: Treating shrimp post-larvae with probiotics during the early stages of development establishes a beneficial microbial community in the gut, laying the foundation for a healthy life cycle.

Challenges and Considerations

While the use of probiotics in shrimp aquaculture holds tremendous potential, it is essential to address challenges such as:

Selection of Strains: Identifying the most effective probiotic strains for a specific shrimp species and environmental conditions is crucial.

Dosage and Timing: Determining the optimal dosage and timing of probiotic administration requires careful consideration to achieve maximum benefits.

Environmental Factors: Factors like water temperature, pH, and salinity can influence the effectiveness of probiotics, making it necessary to tailor applications to specific conditions.

Probiotic solution for shrimp farming from Sanzyme Biologics

Sanzyme Biologics has positioned itself at the forefront of innovation by offering a specialized probiotic solution for aquaculture designed to tackle the unique challenges faced by shrimp farmers. Their approach is holistic, targeting the host, pathogen, and environment to fortify shrimp health and resilience.

Host Support: Sanzyme’s probiotics are formulated to enhance the shrimp’s immune system and digestive processes. By fostering a balanced gut microbiota, these probiotics contribute to improved nutrient absorption and overall health for shrimps.

Pathogen Control: The probiotic solution from Sanzyme Biologics includes strains that compete with and inhibit the growth of harmful pathogens. This proactive approach helps prevent disease outbreaks and reduces mortality rates.

Environmental Management: Recognizing the impact of environmental factors, Sanzyme’s probiotics for aquaculture aid in maintaining optimal conditions within shrimp ponds. This includes mitigating the effects of fluctuating temperatures, salinity levels, and other stressors.

While the financial toll of high mortality rates in shrimp farming is difficult to quantify precisely, Sanzyme Biologics’ probiotic solution aims to significantly reduce these losses. By offering a more predictable and consistent harvest, shrimp farmers can experience increased profitability and sustainability, reinforcing the economic viability of the entire industry.

About Sanzyme Biologics

Sanzyme Biologics is a pioneer in fermentation technology with 50 years of legacy in the area of probiotics.  Founded as Uni-Sankyo in the year 1969, it was the first company to manufacture and sell probiotics & enzymes in India and is today a market leader with presence in over 40 countries across the globe, including key markets such as US, Europe, Japan, South Korea, Australia, New Zealand, China and Taiwan.

Sanzyme Biologics manufactures proprietary probiotic strains, probiotic blends, enzymes and nutritional ingredients for humans, pets and farm animals in its state-of-the-art manufacturing facility in Hyderabad, India with over fermentation capacity of 350,000 L (one of the highest in the world). Sanzyme Biologics is certified FAMI-QS, NON-GMO, NSF, HALAL, KOSHER & ISO   Producing a wide range of spore forming, shelf and process stable probiotic strains. In Animal Health -Sanzyme Biologics  exports AMR Gene Free Probiotic strains of Bacillus subtilis (SAN 144BS), Bacillus coagulans (SAN 135BC), Bacillus licheniformis (SAN 136BL) & Saccharomyces boulardii (SAN 158SB). SANZYME BIOLOGICS also export other Probiotic Animal Health Formulations for Poultry, Aqua, Swine, Dairy, Sheep, Companion Animals & Others

Bacillus clausii Oral Suspension: Effective probiotics shots


The human body is home to trillions of microorganisms that play a pivotal role in maintaining our health. Among these microorganisms, probiotics are gaining popularity due to their potential health benefits. Bacillus clausii, a probiotic strain, has been the subject of considerable research and has shown promising effects on various health conditions. One of the common forms of Bacillus clausii is the oral suspension, which has gained widespread recognition for its ease of use and potential therapeutic properties. In this blog, we will delve into the world of Bacillus clausii oral suspension, exploring its uses, benefits, dosage, side effects, and current research findings.

What is Bacillus clausii oral suspension?

Bacillus clausii is a spore-forming, Gram-positive bacterium that naturally resides in the soil. It has been identified as a probiotic with the ability to form spores, which can withstand adverse conditions such as heat, acidity, and other harsh environments. Due to this unique characteristic, Bacillus clausii can survive the acidic environment of the stomach and reach the intestine in an active form, where it exerts its beneficial effects

The Mechanism of Action

Bacillus clausii oral suspension operates by restoring and maintaining a balanced gut flora. The gastrointestinal tract is home to a complex community of microorganisms, collectively known as the gut microbiota, which plays a crucial role in digestive health, immune function, and overall well-being. Stress, poor dietary habits, antibiotic use, and various other factors can disrupt this delicate balance, leading to gastrointestinal disturbances.

When ingested, Bacillus clausii colonizes the gut and competes with harmful bacteria for nutrients and space, thereby promoting a healthier gut environment. It also produces antimicrobial substances, such as bacteriocins, which directly inhibit the growth of harmful bacteria. Furthermore, Bacillus clausii has been shown to stimulate the production of immunoglobulins, which enhance the immune response and help fight off infections.

Uses of Bacillus clausii Oral Suspension

Gastrointestinal Disorders: Bacillus clausii oral suspension is commonly used to alleviate symptoms associated with gastrointestinal disorders. These disorders include acute diarrhoea, chronic diarrhoea, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD). Clinical trials have demonstrated that Bacillus clausii can reduce the duration and severity of diarrhoea episodes, making it an effective adjuvant treatment.

 Antibiotic-Associated Diarrhoea (AAD): One of the most common side effects of antibiotic use is diarrhoea, which occurs due to the disruption of the gut microbiota. Bacillus clausii has been shown to reduce the risk of AAD by maintaining the balance of the gut microbiota during antibiotic therapy.

Prevention of Recurrent Respiratory Tract Infections (RTIs): Bacillus clausii has immune-modulating properties that may help reduce the recurrence of respiratory tract infections, such as common colds and flu.

Irritable Bowel Syndrome (IBS): Some studies suggest that Bacillus clausii may provide relief from IBS symptoms, such as bloating, gas, and abdominal discomfort, although further research is needed to establish its efficacy.

Allergies and Atopic Dermatitis: Early research indicates that Bacillus clausii might help in managing allergic conditions and atopic dermatitis due to its immunomodulatory effects.

Dosage and Administration of Bacillus clausii oral suspension

The dosage of Bacillus clausii oral suspension can vary depending on the patient’s age, condition, and severity of symptoms. It is crucial to follow the healthcare professional’s advice or the manufacturer’s instructions regarding dosage and administration.

In general, the oral suspension is available in single-dose vials or multi-dose bottles. It is usually taken orally, directly or mixed with water or other beverages. Shake the bottle well before use to ensure an even distribution of the spores.

For adults and children, the recommended dosage may range from 1 to 2 vials per day, divided into two to three doses. Children under two years of age may require a lower dosage. Always consult a healthcare professional, especially when administering Bacillus clausii to infants or young children.

Sanzyme Biologics expertise in manufacturing Bacillus clausii oral suspension

If you are seeking a reliable and experienced partner for private label manufacturing of Bacillus clausii oral suspension, with a proven track record in the pharmaceutical industry, Sanzyme Biologics is your go-to solution for high-quality probiotic products. As a leading contract manufacturer, we understand the critical importance of producing safe, effective, and compliant products that meet your brand’s unique requirements.

Expertise in Probiotic Formulations:   At Sanzyme Biologics, our team of skilled scientists and researchers are well-versed in probiotic formulations and the specific needs of Bacillus clausii oral suspension production. We utilize state-of-the-art technology and adhere to stringent quality control measures throughout the manufacturing process. From strain selection and culture development to formulation and packaging, every step is carefully optimized to ensure the highest quality end product.

Flexible and Customizable Solutions: We understand that each brand has its own identity and target market. With our private label manufacturing services, you have the flexibility to customize the Bacillus clausii oral suspension to align perfectly with your brand’s vision and objectives. Our team works closely with you to understand your requirements and offer tailored solutions, including variations in dosage, packaging, and product presentation.

Quality Assurance and Compliance: At Sanzyme Biologics, quality assurance is at the core of everything we do. We are committed to adhering to the highest industry standards and regulations. Our manufacturing facilities are equipped with cutting-edge technologies and comply with Good Manufacturing Practices (GMP). Additionally, our team of experts ensures that each batch of Bacillus clausii oral suspension undergoes rigorous testing for potency, purity, and safety, providing you and your customers with peace of mind.

Efficient Production and Timely Delivery: Time is of the essence in the fast-paced pharmaceutical industry, and we understand the importance of timely delivery. With streamlined production processes and an efficient supply chain, we strive to meet your manufacturing deadlines promptly without compromising on quality. Our dedication to meeting timelines ensures that your brand can launch and distribute Bacillus clausii oral suspension products to the market with confidence.

Regulatory Support: Navigating the regulatory landscape can be complex, but you don’t have to do it alone. Sanzyme Biologics provides comprehensive regulatory support to ensure that your Bacillus clausii oral suspension complies with all applicable regulations and requirements. Our team is well-versed in regulatory frameworks across various regions, enabling us to help you obtain the necessary certifications and approvals for seamless market entry.

Long-Term Partnership: Choosing Sanzyme Biologics as your private label manufacturing partner means forging a long-term collaboration. We prioritize building strong and lasting relationships with our clients, providing ongoing support even after product delivery. As your trusted partner, we are committed to helping your brand grow and succeed in the competitive probiotics market.

When it comes to private label manufacturing of Bacillus clausii oral suspension, Sanzyme Biologics stands as a dependable and experienced partner. Our expertise in probiotic formulations, commitment to quality and compliance, flexible and customizable solutions, and efficient production processes make us the ideal choice for your brand. With Sanzyme Biologics by your side, you can be confident in delivering top-notch Bacillus clausii oral suspension products that meet the highest industry standards and cater to your target market’s needs. Partner with us today to embark on a successful probiotics journey and achieve mutual success in the thriving healthcare industry.


History and Benefits of a Soil Based Probiotic: Bacillus Coagulans SNZ 1969

Soil-based probiotics have been touted for their sturdiness, longer shelf life and ability to improve digestion, stimulate the immune system, and help maintain a healthy gut microbiota. So, should you be taking soil-based probiotics?

What are soil-based organisms?

The term soil-based organism (SBO) encompasses over 100 different species of microbes naturally found in soil. Some of these have been isolated and adapted for use as probiotics. Most SBO used in soil-based probiotics are spore-forming. This means that when they replicate, they form a small spore that is protected by a hard coating, making them resistant to heat and acid.  This also means that they are more likely to survive the upper gastrointestinal tract and reach the large intestine compared to other commonly used probiotic strains.

Common soil-based species used in probiotics:

Some of the most commonly used soil-based microbes:

  1. Bacillus coagulans
  2. Bacillus subtilis
  3. Bacillus clausii
  4. Bacillus licheniformis
  5. Clostridium butyricum

Disadvantages of traditional/vegetative probiotics

Traditional probiotics strains are mainly BifidobacteriumEnterococcus, and Escherichia etc.  Although traditional probiotics are safe and effective treatment options but they have some shortcomings such as limited shelf life and can get damaged by stomach acid which eventually will lead to reduced efficacy.

Are soil based probiotics good for us?

These probiotics in addition to conferring various health benefits such as normalize bowel function, aid in digestion, beneficially stimulate the immune system, are well known for their ability to resist stomach acid and longer shelf life because of its spore forming attribute.

On the other hand, few opponents of SBOs argue that because of their spore-forming nature, they proliferate rapidly, and may compete with our resident gut microbes, rather than helping to bring the gut microbiota back to normalcy.

However, several individual SBO strains have been shown to be beneficial, with no adverse effects, in dozens of randomized, placebo-controlled, human clinical trials.

Rather than labeling all SBOs as good or bad, we need a more nuanced discussion – one that considers the evidence for each particular strain, microbe, and formula.

Bacillus Coagulans SNZ 1969

Bacillus coagulans is a gram-positive bacterium that produces L-lactic acid. There are different strains of Bacillus coagulans that are used as probiotic to improve and maintain ecological balance of the intestinal microflora. Several experimental studies, including subchronic toxicity, chronic toxicity, reproduction toxicity, in vitro and in vivo genotoxicity and human clinical trials, have appeared with Bacillus coagulans. All these studies support the safety in use of B. coagulans at the intended use levels. Sanzyme Limited has conducted a series of phenotypic and genotypic studies of B. coagulans SNZ1969 strain. These studies further support the non-toxigenic and non-pathogenic nature of this strain. On the basis of scientific procedures, the consumption of B. coagulans SNZ 1969 spores’ preparation, as a food ingredient, is safe.

Legacy of Bacillus coagulans SNZ 1969

This particular strain originated in Japan. In 1949, a Japanese physician, Dr. Nakamura isolated B. coagulans from green malt. This particular isolate was tested for its potential effects against diarrhea and constipation in adult as well as infants during 1964. In 1972, at the request of Sankyo Corporation, the Japanese Ministry of Health and Welfare approved the use of this particular B. coagulans (designated as strain SANK 70258). Subsequently, in 1973, Sankyo Corporation (currently known as Daiichi Sankyo Co. Ltd) offered formulation and fermentation technology to Sanzyme Limited (earlier known as Uni-Sankyo Ltd). Since then, it is marketed in India under the brand name Sporlac and has been designated as strain SNZ 1969.

The Invincible Probiotic

With a naturally-protective outer layer, Bacillus coagulans SNZ 1969 can survive hostile gastric and bile acids in human gut and remain stable in highly acidic (pH2) environment. It is also resistant to high temperature i.e. up to 85°C for 30 min. From production to consumption, it does not show decrement in viability of cell. It sustains extreme manufacturing processes like fermentation, freezing, thawing, drying, and rehydration, making it the ideal probiotic for food applications.

Current Applications of Bacillus coagulans

Bacillus coagulans are used as dietary supplement probiotics for human consumption. These supplements contain B.coagulans alone or in combination with other probiotics and prebiotics. The recommended dose of B. coagulans ranges from 3.8x 108 or 1.5x 109   CFU/capsule, once to thrice daily for an adult. B.coagulans SNZ 1969 had been approved by various clinical studies for treatment of symptoms caused by abnormalities of intestinal flora called gut dysbiosis. It is also used for treatment of oral and vaginal health.

FDA’s Center for Veterinary Medicine has approved use of B. coagulans for veterinary purposes. It has been shown by various studies to improve the feed conversion ratio, ultimately improving the growth performance for animals such as cattle, swine, poultry, aquaculture etc.

Approval and Certifications

Bacillus coagulans SNZ 1969 SNZ 1969 is a well-studied and documented strain with 20+ clinical trials and multiple regulatory approvals (FDA GRAS, Infant GRAS, EFSA QPS, Health Canada, FSSAI and others). It is currently sold and used in 35+ countries including USA, Italy, Canada, Australia and Japan.


It is important for the consumer/buyer to understand the probiotics available in the market and make an informed decision based on the evidence available before purchasing.  As we have seen that not all probiotic strains are equal, the choice of probiotic , that is , whether to go for a traditional(vegetative) or soil- based spore forming probiotic, needs to be made based on which one provides the maximum benefits. A soil based probiotic with its spore forming capability offers more benefits than the traditional ones and Sanzyme Biologics’ Bacillus coagulans SNZ 1969 is a highly stable, spore forming probiotic which has a shelf life of 36 months and can remain viable through various food based application processing, and can easily sustain the low pH of stomach acid. The increased stability opens up multiple avenues of usage and application for the food/ pharma/animal feed manufacturer requirement.

Probiotic Strain for dogs

Probiotics for Pet

In recent years, probiotics have become increasingly popular for pets, as they can provide similar benefits for pets as they do for humans.  As pet owners, everyone wants to ensure that their furry friends are healthy and happy. One way to achieve this is by incorporating probiotics into their diet. Probiotics are live microorganisms that can provide health benefits to pets, including dogs and cats

Probiotics have been widely acknowledged for their ability to enhance the population of beneficial gut bacteria, which play a crucial role in food digestion and overall well-being. However, it is important to note that not all the probiotics are the same as they vary in stability and efficacy.  An ideal probiotic strain needs to be compatible with pet food formulations, process condition, distribution channel and scientifically studied for its safety and efficacy.

Is it necessary to give probiotics to dogs?

Probiotics can help regulate the gut microbiota and maintain digestive health in dogs. Typically, a healthy dog can naturally maintain a balanced microbial population in the gut. However, when a dog experiences stress, illness, or malnutrition, the microbial balance can be disrupted. Probiotic supplements can be beneficial for dogs that have an imbalanced gut microbiota and have shown positive results.

What are the benefits of probiotics for pets?

Probiotics can have several benefits for pets, including:

Improved digestion: Probiotics can help pets digest their food more efficiently and absorb nutrients optimally.

Strengthened immune system: Probiotics can enhance the immune system by promoting the growth of beneficial bacteria and reducing harmful bacteria in the gut.

Reduced inflammation: Probiotics can reduce inflammation in the gut, which can help alleviate symptoms of digestive issues and allergies.

Better overall health: Probiotics can help improve pets’ overall health by supporting their digestive and immune systems.

How can probiotics be given to pets ?

There are several ways to give probiotics to your pet, including:

Probiotic supplements: Probiotic supplements are available in different forms, such as capsules, powders, and chews. You can mix the supplement with your pet’s food or give it to them directly.

Probiotic-enriched pet food: Some pet foods are enriched with probiotics, so you can feed your pet a balanced diet while also promoting a healthy gut.

Probiotics can be a valuable addition to your pet’s diet, especially if they have digestive issues or have been on antibiotics.  At Sanzyme Biologics, we are committed to providing the Probiotic strain which supports the health and well-being of pets. Our team of experts has years of experience in probiotic strains and formulations.

Bacilllus Coagulans SNZ 1969

Bacillus coagulans SNZ 1969® probiotic health claims published in Australia and New Zealand by FSANZ

Sanzyme Biologics performs a systemic review of evidence and publishes a range of health claims for
its flagship probiotic strain Bacillus coagulans SNZ 1969® with FSANZ. Standard 1.2.7 of the Food
Standards Code provides a route for the food industry to self-substantiate a food-health relationship
in order to make a general level health claim. It requires a systematic review demonstrating a causal
association between the food and the health effect.

SNZ 1969® already has USFDA GRAS (Adult & Infant), Health Canada Approval, FSSAI licence and its
manufacturing facility is registered for exports in Japan and China. With the recent claim notification
in FSANZ- SNZ 1969® is well positioned for usability in key probiotic markets across the globe.

Bacillus coagulans SNZ 1969® is backed by 30 human studies and a five-decade history of use
demonstrating its safety and efficacy. SNZ 1969®_ is scientifically studied for gut, oral and women’s
health benefits. Today, it is marketed in over 40 countries across the globe. Being a hardy natural
spore forming probiotic strain, it doesn’t require a cold chain and is used in a range of processed
food and beverage product formats.

Sanzyme Biologics is a pioneer in probiotics and has five decades of expertise in fermentation
technology. Founded in the year 1969 as Uni-Sankyo in joint venture with Sankyo, Japan. It was the
first company to manufacture and sell probiotics under the SPORLAC brand in India. Since then, it
has evolved and transformed into a global leader in shelf and process stable probiotic solutions.

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