Bacillus Coagulans SNZ 1969

Bacillus coagulans SNZ 1969 is an extensively studied and used probiotic strain with a five-decade history of use demonstrating its safety and efficacy across age groups promoting gut health, oral health and women health

Our FDA GRAS approved flagship strain: Bacillus coagulans SNZ 1969™ is unique in the space of spore forming probiotic strains. It boasts an exceptional history of use, stability profile, research and genetic pedigree. Combined with Sanzyme’s experience in end-to-end production and decades of continuous technological improvement, SNZ 1969™ is a reliable, long term choice for inclusion in probiotic formulations in supplements, food, and pharmaceuticals.

  • 50+ Years of safe use across age groups
  • Most studied and used Bacillus coagulans probiotic strain
  • 150+ Million doses in 40+ countries annually

Global Acceptance And Regulatory Registrations

SNZ 1969 probiotic is being used in over 40 countries across the globe. It has USFDA GRAS (Adult and Infants), QPS in European Union, Health Canada approval, facility
accredited with Japanese ministry of health and permitted for use in many other countries across the globe including China, India, Australia, New Zealand, South Korea
and others.

Efficacy proven with more than 30 human studies

Bacillus coagulans SNZ 1969 probiotic health benefits are supported by sound scientific
evidence and substantiate the claim that are globally important to customers

Bacillus coagulans SNZ 1969 stands as a testament to decades of rigorous research, supported by over 30 human clinical studies, with 25 conducted independently. First studied in 1977, it boasts over 50 years of comprehensive investigation. SNZ 1969 has consistently demonstrated its efficacy in promoting gut health, oral health, and women’s health. Furthermore, the research suggests its potential to enhance amino acid absorption for better protein digestion and absorption. With a robust foundation of scientific evidence, Bacillus coagulans SNZ 1969® emerges as a trusted probiotic in supporting overall well-being.


Evaluation of efficacy and safety of Bacillus coagulans SNZ 1969 supplementation for irritable bowel syndrome: a randomized, double-blind,
placebo-controlled study.
Soman R.J., Gorantla S.C., Swamy M.V., International Journal of Basic &
Clinical Pharmacology, 2022. Nov;11(6)

Efficacy and Safety of Probiotic Bacillus coagulans- SNZ 1969 in
Gastrointestinal Discomfort: A Randomized, Placebo-Controlled Study.
Soman R.J., Singh K., Swamy M.V. International Journal of Health Sciences
and Research, 2022. Vol.12; Issue: 3

Spore-forming Bacillus coagulans SNZ 1969 improved intestinal motility and
constipation perception mediated by microbial alterations in healthy adults
with mild intermittent constipation: A randomized controlled trial.
Kang S., Park M.Y., Brooks I., Lee J., Kim S. H., Kim J. Y., Oh B., Kim J.W., Kwon O. Food Research International 2021. 146, 110428

The Efficacy and Safety of Combined Senna & Probiotic-Based Bowel
Preparation for Colonoscopy in Children.
Kesavelu D. Cureus, 2020. 12 (9): e10180.

Clinical trial of Sporlac in gastroenteritis.
Ronald Ross Institute of Tropical Diseases, Hyderabad. 1999 (Unpublished)

Comparative evaluation of locally delivered probiotic paste and
chlorhexidine gel as an adjunct to scaling and root planning in treating
chronic periodontitis: A split-mouth randomized clinical trial.
Vishnusripriya J., Melath A., Feroz M., Subair K., and Chandran N J Indian Soc Periodontol. 2022. May-Jun; 26(3): 262–268.

SNZ 1969 offer choices to various formats and application in diverse functional foods

Flexibility & stability


Bacillus coagulans SNZ 1969 distinguishes itself as a resilient spore-forming probiotic strain, showcasing remarkable hardiness in various conditions. Its ability to construct a protective spore encased in a calcium-lipicolinic acid peptidoglycan complex ensures durability and survival until favorable circumstances arise. Remaining in a dormant state until conditions become conducive, it requires no refrigeration, offering practicality in storage and transportation. This resilience extends to enduring processing conditions and the gastrointestinal environment, ensuring its efficacy throughout its journey. With its robust nature, Bacillus coagulans opens doors to unlimited application opportunities, promising versatility and effectiveness across diverse products and industries.



SNZ 1969 effectively survives gastric conditions as against conventional vegetative strains, resulting in efficacy at relatively lower dosages.

The exceptional stability of SNZ 1969 enhances your pricing competitiveness, profitability and assurance of meeting product label claim with less overage compared with the traditional probiotic strain.

Easy to formulate functional food and supplements with SNZ 1969®

Right Selection Leads to success


SNZ 1969 is thermal and process stable which makes it easy to formulate in a wide variety of conventional food formats, with health benefits. SNZ 1969 is stable in
wide variety of food products such as cereals, muesli, granola, chocolate, tea, coffee, health beverages, spreads, hard boiled candies, chews, gums, kombucha, juices,
puree, smoothies, protein bars, cereal bars, porridges, bread, cakes and more.


Gummies, capsule, sachets, protein supplement, meal replacement and more


Application Support Services

Sanzyme Biologics’ application team has decades of experience in studying the incorporation and stability of probiotic strain in various matrixes and work closely to advise on the best possible approach. We’re here to assist you every step of the way, from initial ideation and prototyping to formulation, cell-count stability testing, production, marketing, and ongoing technical support.

Production in a Dedicated NSF Certified Facility

Sanzyme Biologics meticulously manages every step of probiotic production, maintaining stringent control over inputs and process parameters from flask cultivation to seed fermenters, through full-scale fermentation, and culminating in blending and spray drying. With extensive experience in spore-forming probiotics, our dedication to producing superior quality spores is unwavering. At Sanzyme Biologics, we have dedicated NSF certified plant specifically for the production of Bacillus coagulans, ensuring the highest standards of quality and safety in every step of the process.

Bacillus coagulans Sanzyme Biologics plants


  • Bacillus coagulans SNZ 1969 has been safely consumed by humans for over 50 years. This makes it one of the oldest, best studied and well characterized probiotics available in the market today. The strain initially isolated in Japan. In 1949, a Japanese physician, Dr. Nakayama isolated B. coagulans from green malt. This particular isolate was tested for its potential effects against diarrhea and constipation in adult as well as infants during 1964.
    In 1972, at the request of Sankyo Corporation, the Japanese Ministry of Health and Welfare approved the use of this particular B. coagulans. Subsequently, in 1973, Sankyo Corporation (currently known as Daiichi Sankyo Co. Ltd) offered formulation and fermentation technology to Sanzyme Biologics Private Limited, India (earlier known as Uni Sankyo Ltd.). Since then, it has been marketed in India under the brand name “Sporlac” for the past 50 years and has been used as a probiotic with no adverse effects reported so far. In the year 2010 the strain was formally designated as SNZ 1969 by Sanzyme

Natural spore former
Acid & Bile tolerant
Does not require refrigeration
Isolated from green malt
Long shelf life
Transient colonizer
Lactic acid producer


50 years of safe use
Used across age group infants, children, adults & old
Requires less overages
Studied at various dosage form 100 million CFU to
2 billion CFU per serve

Safety & Efficacy

Proven safety
Genetically characterized strain
Clinically studied > 30 human studies
Studied for gut health, oral health &
women health