Antibiotic growth promoters (AGPs) have been extensively employed in poultry farming to accelerate growth rates, improve feed conversion ratios, and to reduce disease incidence in the past, Use of AGPs lead to antimicrobial resistance (AMR), which pose risks to both animal and human health. AMR is transfered from animals to humans through the food chain via plasmid transfer amongst the microbes both in vivo and in vitro, posing a serious public health threat. Additionally, AGPs disrupt the gut microbiota in poultry, weakening their natural immunity. These issues have led to restrictions of AGPs and increased preference for safer alternatives like probiotics and plant-based additives.
What are Synbiotics?
Synbiotics are a synergistic combination of:
- Probiotics: Live beneficial microorganisms that improve gut health.
- Prebiotics: Non-digestible food ingredients that enhance immunity of host and also support for probiotic propagation.
Together, they enhance nutrient absorption, boost immunity and promote the growth of beneficial gut flora, making them a powerful alternative to AGPs.
Benefits of Synbiotics in Poultry:
Studies and trials by independent researchers have demonstrated that Synbiotics:
1. Improved Growth Performance
Synbiotic supplementation significantly improved body weight and feed conversion ratio (FCR).
2. Enhanced Digestibility
Protein and energy digestibility were enhanced in birds supplemented with Synbiotics as a result of better nutrient absorption.
3. Boosted Immunity
Birds showed higher antibody titers against Newcastle Disease and Infectious Bursal Disease, along with improved immune cell activity – suggesting strong immune modulation by synbiotics.
4. Better Gut Health
Synbiotics enhanced gut morphology, reduced gut inflammation, and supported good digestion, crucial for bird health and feed efficiency.
5. Safe Alternative to Antibiotics
The Synbiotic products matched or outperformed AGPs in most parameters, without the risk of antibiotic residues or antimicrobial resistance (AMR).
6. Higher Carcass Yield
Ready-to-cook (RTC) weight was improved in Synbiotic-fed birds, supporting superior Returns on investment (ROI).
7. Improved Litter Quality
Synbiotics reduced faecal water-soluble phosphorus (WSP) and maintained drier, healthier litter, which helped reduce footpad lesions and disease risks.
8. Enhanced Overall Health
Serum biochemical parameters (liver and kidney markers) remained within normal ranges, confirming the safety of Synbiotics.
SPORICH-total+βgM: Synbiotic formulation developed by Sanzyme Biologics
SPORICH-total+βgM is a full-spectrum Synbiotic formulation developed by Sanzyme Biologics. SPORICH-total+βgM combines multiple robust probiotic strains with potent prebiotic components to offer comprehensive gut protection from Crop-to-Cloaca.
Key Ingredients:
- Bacillus subtilis (SAN 144BS)
- Bacillus coagulans (SAN 135BC)
- Bacillus licheniformis (SAN 136BL)
- Saccharomyces boulardii (SAN 158SB)
- β-Glucans ≥ 30%
- Mannan-Oligosaccharides ≥ 15%
SPORICH-total+βgM is a proprietary blend is Non-GMO, AMR gene-free, Non-Haemolytic, Sporulating and Viable, making it ideal for poultry application.
Mechanism of Action of SPORICH-total+βgM:
Probiotics:
- Produce VFA’s (Acetic, Butyric, Propionic & Lactic acids) for energy
- Acidify the gut to suppress pathogens
- Generate bacteriocins like Nisin, Lecucocin, Pediocin, Reuterin, Colicin, Subtilin and Coagulin to kill harmful microbes
- Secrete digestive enzymes (amylase, protease, lipase) for superior nutrient absorption
- Modulate gut morphology by improving V/C ratio
- Prevent Diarrhea/Loose droppings through polyamines that tighten intestinal junctions
β-Glucans & MOS:
- Activate the immune system
- Improve intestinal barrier function
- Reduce pathogen load while supporting beneficial microbiota
Comparative Results of SPORICH-total+βgM vs. Probiotic vs. Prebiotic vs. AGP (at 6 Weeks):
| Parameter | SPORICH-total+βgM vs Control | SPORICH-total+βgM vs Probiotic | SPORICH-total+βgM vs Prebiotic | SPORICH-total+βgM vs AGP |
| V/C Ratio (Jejunum) | 10.29% | 5.50% | 9.20% | 2.26% |
| Serum Protein (g/dL) | 62.82% | 15.06% | 23.13% | 36.20% |
| Body Weight Gain (kg) | 4.91% | 3.19% | 6.39% | 0.37% |
| Feed Conversion Ratio (FCR) | -4.38% | -3.16% | -4.38% | -1.56% |
| Dressing Weight (%) | 2.31% | 1.66% | 1.96% | 3.52% |
| Lactobacilli Count (Ileum) | 12.32% | 1.83% | 1.05% | 2.92% |
| E. coli Count (Ileum) | -28.75% | -26.02% | -26.93% | -5.51% |
In a 6-week broiler trial, SPORICH-total+βgM proved to be more effective than antibiotic growth promoters (AGPs) across key performance indicators. It improved gut health with a Better Villus Height to Crypt Depth Ratio and Boosted Serum Protein Levels by 36.2%, indicating stronger metabolism. Birds supplemented SPORICH-total+βgM showed 0.37% more weight gain and a 1.56% Better Feed Conversion Ratio compared to those on AGPs. Dressing Weight was also 3.52% higher. Additionally, it Increased Good Gut Bacteria (Lactobacilli sp,) And Reduced Harmful E. coli more efficiently. These results show SPORICH-total+βgM is a safe and powerful alternative to antibiotics in poultry farming.
Benefits of SPORICH-total+βgM:
- Increases nutrient availability and absorption
- Effectively controls pathogenic bacteria
- Increases average body weight at market age
- Optimizes feed conversion ratio (FCR)
- Improves net economic profit per kilogram of sale
- Reduces wet litter and ammonia production
Available as feed additive in 4 Billion CFU/g and 8 Billion CFU/g Potencies
Feed Inclusion Rate for SPORICH-total 4B+βgM: 250–500 g / MT
References:
- T. Srilatha, Ph.D. & Dr. M. Hanmanth Rao, Ph.D – “A research project report on the evaluation of the efficacy of synbiotic (SPORICH-total+βgM) supplementation as an alternative to antibiotic usage in commercial chickens.”
- Vishwanath G Bhagwat , Santoshkumar V G Tattimani , Mirza Rizwan Baig- “Dietary Supplementation of Synbiotic Formulation with Phytoactives on Broiler Performance, Relative Ready-to-Cook Weight, Health, Nutrient Digestibility, Gut Health, and Litter Characteristics”