Sanzyme Biologics, Author at Sanzymebiologics

Bacillus clausii Oral Suspension: Effective probiotics shots

Introduction

The human body is home to trillions of microorganisms that play a pivotal role in maintaining our health. Among these microorganisms, probiotics are gaining popularity due to their potential health benefits. Bacillus clausii, a probiotic strain, has been the subject of considerable research and has shown promising effects on various health conditions. One of the common forms of Bacillus clausii is the oral suspension, which has gained widespread recognition for its ease of use and potential therapeutic properties. In this blog, we will delve into the world of Bacillus clausii oral suspension, exploring its uses, benefits, dosage, side effects, and current research findings.

What is Bacillus clausii oral suspension?

Bacillus clausii is a spore-forming, Gram-positive bacterium that naturally resides in the soil. It has been identified as a probiotic with the ability to form spores, which can withstand adverse conditions such as heat, acidity, and other harsh environments. Due to this unique characteristic, Bacillus clausii can survive the acidic environment of the stomach and reach the intestine in an active form, where it exerts its beneficial effects

The Mechanism of Action

Bacillus clausii oral suspension operates by restoring and maintaining a balanced gut flora. The gastrointestinal tract is home to a complex community of microorganisms, collectively known as the gut microbiota, which plays a crucial role in digestive health, immune function, and overall well-being. Stress, poor dietary habits, antibiotic use, and various other factors can disrupt this delicate balance, leading to gastrointestinal disturbances.

When ingested, Bacillus clausii colonizes the gut and competes with harmful bacteria for nutrients and space, thereby promoting a healthier gut environment. It also produces antimicrobial substances, such as bacteriocins, which directly inhibit the growth of harmful bacteria. Furthermore, Bacillus clausii has been shown to stimulate the production of immunoglobulins, which enhance the immune response and help fight off infections.

Uses of Bacillus clausii Oral Suspension

Gastrointestinal Disorders: Bacillus clausii oral suspension is commonly used to alleviate symptoms associated with gastrointestinal disorders. These disorders include acute diarrhoea, chronic diarrhoea, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD). Clinical trials have demonstrated that Bacillus clausii can reduce the duration and severity of diarrhoea episodes, making it an effective adjuvant treatment.

Antibiotic-Associated Diarrhoea (AAD): One of the most common side effects of antibiotic use is diarrhoea, which occurs due to the disruption of the gut microbiota. Bacillus clausii has been shown to reduce the risk of AAD by maintaining the balance of the gut microbiota during antibiotic therapy.

Prevention of Recurrent Respiratory Tract Infections (RTIs): Bacillus clausii has immune-modulating properties that may help reduce the recurrence of respiratory tract infections, such as common colds and flu.

Irritable Bowel Syndrome (IBS): Some studies suggest that Bacillus clausii may provide relief from IBS symptoms, such as bloating, gas, and abdominal discomfort, although further research is needed to establish its efficacy.

Allergies and Atopic Dermatitis: Early research indicates that Bacillus clausii might help in managing allergic conditions and atopic dermatitis due to its immunomodulatory effects.

Dosage and Administration of Bacillus clausii oral suspension

The dosage of Bacillus clausii oral suspension can vary depending on the patient’s age, condition, and severity of symptoms. It is crucial to follow the healthcare professional’s advice or the manufacturer’s instructions regarding dosage and administration.

In general, the oral suspension is available in single-dose vials or multi-dose bottles. It is usually taken orally, directly or mixed with water or other beverages. Shake the bottle well before use to ensure an even distribution of the spores.

For adults and children, the recommended dosage may range from 1 to 2 vials per day, divided into two to three doses. Children under two years of age may require a lower dosage. Always consult a healthcare professional, especially when administering Bacillus clausii to infants or young children.

Sanzyme Biologics expertise in manufacturing Bacillus clausii oral suspension

If you are seeking a reliable and experienced partner for private label manufacturing of Bacillus clausii oral suspension, with a proven track record in the pharmaceutical industry, Sanzyme Biologics is your go-to solution for high-quality probiotic products. As a leading contract manufacturer, we understand the critical importance of producing safe, effective, and compliant products that meet your brand’s unique requirements.

Expertise in Probiotic Formulations: At Sanzyme Biologics, our team of skilled scientists and researchers are well-versed in probiotic formulations and the specific needs of Bacillus clausii oral suspension production. We utilize state-of-the-art technology and adhere to stringent quality control measures throughout the manufacturing process. From strain selection and culture development to formulation and packaging, every step is carefully optimized to ensure the highest quality end product.

Flexible and Customizable Solutions: We understand that each brand has its own identity and target market. With our private label manufacturing services, you have the flexibility to customize the Bacillus clausii oral suspension to align perfectly with your brand’s vision and objectives. Our team works closely with you to understand your requirements and offer tailored solutions, including variations in dosage, packaging, and product presentation.

Quality Assurance and Compliance: At Sanzyme Biologics, quality assurance is at the core of everything we do. We are committed to adhering to the highest industry standards and regulations. Our manufacturing facilities are equipped with cutting-edge technologies and comply with Good Manufacturing Practices (GMP). Additionally, our team of experts ensures that each batch of Bacillus clausii oral suspension undergoes rigorous testing for potency, purity, and safety, providing you and your customers with peace of mind.

Efficient Production and Timely Delivery: Time is of the essence in the fast-paced pharmaceutical industry, and we understand the importance of timely delivery. With streamlined production processes and an efficient supply chain, we strive to meet your manufacturing deadlines promptly without compromising on quality. Our dedication to meeting timelines ensures that your brand can launch and distribute Bacillus clausii oral suspension products to the market with confidence.

Regulatory Support: Navigating the regulatory landscape can be complex, but you don’t have to do it alone. Sanzyme Biologics provides comprehensive regulatory support to ensure that your Bacillus clausii oral suspension complies with all applicable regulations and requirements. Our team is well-versed in regulatory frameworks across various regions, enabling us to help you obtain the necessary certifications and approvals for seamless market entry.

Long-Term Partnership: Choosing Sanzyme Biologics as your private label manufacturing partner means forging a long-term collaboration. We prioritize building strong and lasting relationships with our clients, providing ongoing support even after product delivery. As your trusted partner, we are committed to helping your brand grow and succeed in the competitive probiotics market.

When it comes to private label manufacturing of Bacillus clausii oral suspension, Sanzyme Biologics stands as a dependable and experienced partner. Our expertise in probiotic formulations, commitment to quality and compliance, flexible and customizable solutions, and efficient production processes make us the ideal choice for your brand. With Sanzyme Biologics by your side, you can be confident in delivering top-notch Bacillus clausii oral suspension products that meet the highest industry standards and cater to your target market’s needs. Partner with us today to embark on a successful probiotics journey and achieve mutual success in the thriving healthcare industry.

History and Benefits of a Soil Based Probiotic: Bacillus Coagulans SNZ 1969

Soil-based probiotics have been touted for their sturdiness, longer shelf life and ability to improve digestion, stimulate the immune system, and help maintain a healthy gut microbiota. So, should you be taking soil-based probiotics?

What are soil-based organisms?

The term soil-based organism (SBO) encompasses over 100 different species of microbes naturally found in soil. Some of these have been isolated and adapted for use as probiotics. Most SBO used in soil-based probiotics are spore-forming. This means that when they replicate, they form a small spore that is protected by a hard coating, making them resistant to heat and acid. This also means that they are more likely to survive the upper gastrointestinal tract and reach the large intestine compared to other commonly used probiotic strains.

Common soil-based species used in probiotics:

Some of the most commonly used soil-based microbes:

Bacillus coagulans
Bacillus subtilis
Bacillus clausii
Bacillus licheniformis
Clostridium butyricum

Disadvantages of traditional/vegetative probiotics

Traditional probiotics strains are mainly Bifidobacterium, Enterococcus, and Escherichia etc. Although traditional probiotics are safe and effective treatment options but they have some shortcomings such as limited shelf life and can get damaged by stomach acid which eventually will lead to reduced efficacy.

Are soil based probiotics good for us?

These probiotics in addition to conferring various health benefits such as normalize bowel function, aid in digestion, beneficially stimulate the immune system, are well known for their ability to resist stomach acid and longer shelf life because of its spore forming attribute.

On the other hand, few opponents of SBOs argue that because of their spore-forming nature, they proliferate rapidly, and may compete with our resident gut microbes, rather than helping to bring the gut microbiota back to normalcy.

However, several individual SBO strains have been shown to be beneficial, with no adverse effects, in dozens of randomized, placebo-controlled, human clinical trials.

Rather than labeling all SBOs as good or bad, we need a more nuanced discussion – one that considers the evidence for each particular strain, microbe, and formula.

Bacillus Coagulans SNZ 1969

Bacillus coagulans is a gram-positive bacterium that produces L-lactic acid. There are different strains of Bacillus coagulans that are used as probiotic to improve and maintain ecological balance of the intestinal microflora. Several experimental studies, including subchronic toxicity, chronic toxicity, reproduction toxicity, in vitro and in vivo genotoxicity and human clinical trials, have appeared with Bacillus coagulans. All these studies support the safety in use of B. coagulans at the intended use levels. Sanzyme Limited has conducted a series of phenotypic and genotypic studies of B. coagulans SNZ1969 strain. These studies further support the non-toxigenic and non-pathogenic nature of this strain. On the basis of scientific procedures, the consumption of B. coagulans SNZ 1969 spores’ preparation, as a food ingredient, is safe.

Legacy of Bacillus coagulans SNZ 1969

This particular strain originated in Japan. In 1949, a Japanese physician, Dr. Nakamura isolated B. coagulans from green malt. This particular isolate was tested for its potential effects against diarrhea and constipation in adult as well as infants during 1964. In 1972, at the request of Sankyo Corporation, the Japanese Ministry of Health and Welfare approved the use of this particular B. coagulans (designated as strain SANK 70258). Subsequently, in 1973, Sankyo Corporation (currently known as Daiichi Sankyo Co. Ltd) offered formulation and fermentation technology to Sanzyme Limited (earlier known as Uni-Sankyo Ltd). Since then, it is marketed in India under the brand name Sporlac and has been designated as strain SNZ 1969.

The Invincible Probiotic

With a naturally-protective outer layer, Bacillus coagulans SNZ 1969 can survive hostile gastric and bile acids in human gut and remain stable in highly acidic (pH2) environment. It is also resistant to high temperature i.e. up to 85°C for 30 min. From production to consumption, it does not show decrement in viability of cell. It sustains extreme manufacturing processes like fermentation, freezing, thawing, drying, and rehydration, making it the ideal probiotic for food applications.

Current Applications of Bacillus coagulans

Bacillus coagulans are used as dietary supplement probiotics for human consumption. These supplements contain B.coagulans alone or in combination with other probiotics and prebiotics. The recommended dose of B. coagulans ranges from 3.8x 10⁸ or 1.5x 10⁹CFU/capsule, once to thrice daily for an adult. B.coagulans SNZ 1969 had been approved by various clinical studies for treatment of symptoms caused by abnormalities of intestinal flora called gut dysbiosis. It is also used for treatment of oral and vaginal health.

FDA’s Center for Veterinary Medicine has approved use of B. coagulans for veterinary purposes. It has been shown by various studies to improve the feed conversion ratio, ultimately improving the growth performance for animals such as cattle, swine, poultry, aquaculture etc.

Approval and Certifications

Bacillus coagulans SNZ 1969 SNZ 1969 is a well-studied and documented strain with 20+ clinical trials and multiple regulatory approvals (FDA GRAS, Infant GRAS, EFSA QPS, Health Canada, FSSAI and others). It is currently sold and used in 35+ countries including USA, Italy, Canada, Australia and Japan.

Conclusion

It is important for the consumer/buyer to understand the probiotics available in the market and make an informed decision based on the evidence available before purchasing. As we have seen that not all probiotic strains are equal, the choice of probiotic , that is , whether to go for a traditional(vegetative) or soil- based spore forming probiotic, needs to be made based on which one provides the maximum benefits. A soil based probiotic with its spore forming capability offers more benefits than the traditional ones and Sanzyme Biologics’ Bacillus coagulans SNZ 1969 is a highly stable, spore forming probiotic which has a shelf life of 36 months and can remain viable through various food based application processing, and can easily sustain the low pH of stomach acid. The increased stability opens up multiple avenues of usage and application for the food/ pharma/animal feed manufacturer requirement.

Probiotics for Pets

In recent years, probiotics have become increasingly popular for pets, as they can provide similar benefits for pets as they do for humans. As pet owners, everyone wants to ensure that their furry friends are healthy and happy. One way to achieve this is by incorporating probiotics into their diet. Probiotics are live microorganisms that can provide health benefits to pets, including dogs and cats

Probiotics have been widely acknowledged for their ability to enhance the population of beneficial gut bacteria, which play a crucial role in food digestion and overall well-being. However, it is important to note that not all the probiotics are the same as they vary in stability and efficacy. An ideal probiotic strain needs to be compatible with pet food formulations, process condition, distribution channel and scientifically studied for its safety and efficacy.

Is it necessary to give probiotics to dogs?

Probiotics can help regulate the gut microbiota and maintain digestive health in dogs. Typically, a healthy dog can naturally maintain a balanced microbial population in the gut. However, when a dog experiences stress, illness, or malnutrition, the microbial balance can be disrupted. Probiotic supplements can be beneficial for dogs that have an imbalanced gut microbiota and have shown positive results.

What are the benefits of probiotics for pets?

Probiotics can have several benefits for pets, including:

Improved digestion: Probiotics can help pets digest their food more efficiently and absorb nutrients optimally.

Strengthened immune system: Probiotics can enhance the immune system by promoting the growth of beneficial bacteria and reducing harmful bacteria in the gut.

Reduced inflammation: Probiotics can reduce inflammation in the gut, which can help alleviate symptoms of digestive issues and allergies.

Better overall health: Probiotics can help improve pets’ overall health by supporting their digestive and immune systems.

How can probiotics be given to pets ?

There are several ways to give probiotics to your pet, including:

Probiotic supplements: Probiotic supplements are available in different forms, such as capsules, powders, and chews. You can mix the supplement with your pet’s food or give it to them directly.

Probiotic-enriched pet food: Some pet foods are enriched with probiotics, so you can feed your pet a balanced diet while also promoting a healthy gut.

Probiotics can be a valuable addition to your pet’s diet, especially if they have digestive issues or have been on antibiotics. At Sanzyme Biologics, we are committed to providing the Probiotic strain which supports the health and well-being of pets. Our team of experts has years of experience in probiotic strains and formulations.

Bacillus coagulans SNZ 1969® probiotic health claims published in Australia and New Zealand by FSANZ

Sanzyme Biologics performs a systemic review of evidence and publishes a range of health claims for
its flagship probiotic strain Bacillus coagulans SNZ 1969® with FSANZ. Standard 1.2.7 of the Food
Standards Code provides a route for the food industry to self-substantiate a food-health relationship
in order to make a general level health claim. It requires a systematic review demonstrating a causal
association between the food and the health effect.

SNZ 1969® already has USFDA GRAS (Adult & Infant), Health Canada Approval, FSSAI licence and its
manufacturing facility is registered for exports in Japan and China. With the recent claim notification
in FSANZ- SNZ 1969® is well positioned for usability in key probiotic markets across the globe.

Bacillus coagulans SNZ 1969® is backed by 30 human studies and a five-decade history of use
demonstrating its safety and efficacy. SNZ 1969®_ is scientifically studied for gut, oral and women’s
health benefits. Today, it is marketed in over 40 countries across the globe. Being a hardy natural
spore forming probiotic strain, it doesn’t require a cold chain and is used in a range of processed
food and beverage product formats.

Sanzyme Biologics is a pioneer in probiotics and has five decades of expertise in fermentation
technology. Founded in the year 1969 as Uni-Sankyo in joint venture with Sankyo, Japan. It was the
first company to manufacture and sell probiotics under the SPORLAC brand in India. Since then, it
has evolved and transformed into a global leader in shelf and process stable probiotic solutions.

SNZ 1969® helps manage IBS-D & IBS-C symptoms effectively, demonstrates the latest clinical study

Bacillus coagulans SNZ 1969®, a natural spore forming probiotic strain with five decades history of use and over 30 human studies across age groups found to be effective in managing IBS symptoms, demonstrates the latest clinical study. This study is unique as it covers both the IBS-D and IBS-C groups with larger number of subjects.

Irritable bowel syndrome (IBS) is one of the most common disorders of gut-brain interaction, estimated to affect around 11% people globally. The outcome of this study will be significant to supplement manufacturers as it can help design products to address consumer need for managing IBS symptoms with a scientifically studied probiotic strain.

In a randomized, double blind, placebo-controlled study¹, probiotic potential (efficacy and safety) of SNZ 1969® has been studied in patients with constipation predominant irritable bowel syndrome (IBS-C) and diarrhea predominant irritable bowel syndrome (IBS-D). Reduction in the GSRS-IBS score was greater in the treatment group (39.78%) compared to the placebo group (2.42%). Consistent reductions in the GSRS-IBS score also seen in patients with IBS-D from baseline (62.5±3.9) to day 75 (34.45±3.53) (p<0.0001) after treatment with SNZ 1969®. The study showed most patients (90%) with IBS-C and 100% with IBS-D responded to SNZ 1969® as compared to no responders treated with placebo, p<0.0001. SNZ 1969® was found to be safe and effective alternative to therapeutic option for IBS patients as it alleviates IBS-associated clinical symptoms and improves the quality of life as compared to placebo.

This study was conduct at Apollo Hospitals, Hyderabad, India and published in the International Journal of Basic & Clinical Pharmacology. https://www.ijbcp.com/index.php/ijbcp/article/view/5120

The same strain has been studied earlier for gastrointestinal discomfort, intestinal motility and intermittent constipation among health subjects. GI discomfort study² showed an improvement in total SODA scores, including specific symptoms such as burping/belching, bloating, heartburn, passing gas, nausea, bad breath, and sour taste compared with placebo. Intestinal motility³ study concluded that SNZ 1969® reaches the colon intact and ameliorates intestinal motility and gut microbiota composition by enhancing lactobacillales and diminishing synergistales. With the latest IBS study, the overall digestive health positioning of SNZ 1969® has been bolstered and made SNZ 1969® an ultimate option for food and supplement manufacturers around the globe.

About Sanzyme Biologics

Sanzyme Biologics was incorporated in 1969 as Uni-Sankyo and was the first company to manufacture and sell probiotics in the Indian market. Over the last five decades Sanzyme Biologics established its strength in probiotics by developing scientifically studied and well-documented probiotic strains, pioneered their applications beyond human health into aqua, veterinary, poultry and bioremediation. Sanzyme Biologics has market presence in over 40 countries across the globe.

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